Diosmin along with other active Flavanoids is more effective in treating the venous disease.

Eur J Vasc Endovasc Surg. 2018 Mar 24. pii: S1078-5884(18)30106-0. doi: 10.1016/j.ejvs.2018.02.009. [Epub ahead of print]

Protective Effects of Micronized Purified Flavonoid Fraction (MPFF)

on a Novel Experimental Model of Chronic Venous Hypertension.

das Graças C de Souza M¹, Cyrino FZ², de Carvalho JJ³, Blanc-Guillemaud V⁴, Bouskela E

CONCLUSION:

 MPFF was more effective than diosmin in improving all microvascular

variables. The superiority of MPFF over diosmin alone can be explained by the synergistic

beneficial effects of the association between diosmin and active flavonoids of MPFF.