Exercise on daily basis seems to be helpful in many ways.
But we still can’t find time to do the regular exercise or many of us take an
excuse for not going for a walk or exercise or play a game to produce sweat.
Exercise is advised to protect the heart, reduce weight, prevent and control
diabetes, hypertension. Many people ask us for an alternative to 30 minute
exercise because they feel that they are wasting another 1 hour they are
needing prepare and get ready to go for work in the morning after exercises.
Some say with a smiling face when will the doctors find a tablet which is equal
to walking exercise and give the same benefits of walking? Some others feel
that they can not walk because of their physical disabilities or leg pains and
they are seriously looking for the alternatives to the regular walking
exercise.
In the recent it was found that exercise actually works on
methylation of the DNA and chemically changes the DNA of the fat tissues in the
body and generates the benefits which we are noticing. The researchers found 24 sites located close to 18 of the
candidate genes for obesity with a difference in DNA methylation in adipose
tissue in response to the exercise intervention. Additionally, two of those
genes (CPEB4 and SDCCAG8) showed significant changes in mRNA expression after
exercise (meaning that the activity of these particular genes was significantly
changed by exercise).
Among the T2D candidate genes, 45 sites in 21 different
genes were differentially methylated in fat tissue before versus after
exercise. Of note, 10 of these sites mapped to KCNQ1 and 6 sites mapped to
TCF7L2-important since TCF7L2 is the gene showing the highest genetic
association with type 2 diabetes. A simultaneous change in mRNA expression was
seen for four of the T2D candidate genes where mRNA expression decreased while
DNA methylation increased in adipose tissue in response to exercise, meaning
that again, the activity of these particular genes was significantly changed by
exercise. The study is by Dr Tina Rönn, Lund University, Malmö, Sweden. She
adds: "Since we also observed DNA methylation changes in genes important for
fat metabolism, which indicates increased fat uptake in response to exercise,
these genes could potentially be a target for future drugs."
May be one day, there may be a pill for some one who can not
do the exercise to get the benefits equal to that exercise. Very interesting
too!! Let us hope so ! Let those also
get the benefit of exercise without exercise.
The Beta3-Adrenergic Receptor Gene: The
Beta3-adrenergic receptor gene makes a protein in fat cells that is
involved in determining how much fuel your body burns when you are resting. A
mutation in this gene slows down how quickly a person burns fat — increasing
their tendency to be obese. One specific mutation in this gene, called TRP64ARG,
is almost four times more common in Pima Indians than in people of European
descent, and is one and a half times more common in people of African or
Mexican descent. The prevalence of the TRP64ARG gene mutation in these
populations probably accounts at least in part for why these ethnic groups have
a higher rate of Type 2 diabetes. The genetics of Type 2 diabetes is
complicated, with many different genes influencing a person's risk. Because of
this array of genes, Type 2 diabetes is not inherited in a clearly dominant or recessive manner.
Instead, a person may have one gene that increases their risk and other genes
that decrease risk. Together, these genes, along with environmental factors,
determine a person's overall risk for developing diabetes. With so many
variables to consider, the medical community is a long way from a genetic
test for Type 2 diabetes. Although there is no genetic test for Type 2
diabetes, the American Diabetes Association recommends screening for diabetes
onset every three years if you have diabetes in the family. Doctors screen for
diabetes onset using a fasting glucose test or glucose tolerance
test, which tells doctors if your blood glucose levels are unusually high.
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