It is our hope that the morbidity and mortality should be much less with introduction of many antidiabetic, antihypertensive and anti lipidemic therapies in the past few decades. In one recent study published in the NEJM.org the absolute changes in the incidence rates of sentinel outcomes per 10,000 person-years were observed in the type 1 and type 2 diabetes patients 198-2012.
Patients with type 1 diabetes had roughly 40% greater reduction in cardiovascular outcomes (CVOs) than controls, and patients with type 2 diabetes had roughly 20% greater reduction than controls. Reductions in fatal outcomes were similar in patients with type 1 diabetes and controls, "whereas patients with type 2 diabetes had smaller reductions in fatal outcomes than controls".
This finding of Swedish doctors from 1998 through 2014, mortality and the incidence of cardiovascular outcomes declined substantially among persons with diabetes, although fatal outcomes declined less among those with type 2 diabetes than among controls, makes us think what could be reason for failure to reduce the fatal outcomes more significantly ? we have introduced so many new ways to treat these patients medically with drugs and interventions! Why these are adding up to reduce the fatal outcomes! in type 2 diabetes. May be we have not understood the pathophysiology adequately and so the corrective measures are not effective too!
Patients with type 1 diabetes had roughly 40% greater reduction in cardiovascular outcomes (CVOs) than controls, and patients with type 2 diabetes had roughly 20% greater reduction than controls. Reductions in fatal outcomes were similar in patients with type 1 diabetes and controls, "whereas patients with type 2 diabetes had smaller reductions in fatal outcomes than controls".
This finding of Swedish doctors from 1998 through 2014, mortality and the incidence of cardiovascular outcomes declined substantially among persons with diabetes, although fatal outcomes declined less among those with type 2 diabetes than among controls, makes us think what could be reason for failure to reduce the fatal outcomes more significantly ? we have introduced so many new ways to treat these patients medically with drugs and interventions! Why these are adding up to reduce the fatal outcomes! in type 2 diabetes. May be we have not understood the pathophysiology adequately and so the corrective measures are not effective too!
Reference:
1). Aidin Rawshani,., Araz
Rawshani, Stefan Franzén, Björn Eliasson,, Ann-Marie Svensson, Mervete Miftaraj,
Darren K. McGuire, Naveed Sattar, Annika Rosengren, and Soffia Gudbjörnsdottir. Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes. N Engl J Med 2017; 376:1407-1418
No comments:
Post a Comment