Monday, November 12, 2012

Blood goups and risk of proximal DVT


What is your blood group? if you have  O+  blood group, then you are probably safer than Non-O blood group people !!!

Non-O blood group in people seems to influence the risk of deep vein thrombosis.  In a study on 712 DVT patients, significant thrombotic risk was noted in those with Non O blood group and thrombophilia. In such patients the risk for DVT can be almost 3-fold higher.


Blood Transfus. 2012 Oct 11:1-5. doi: 10.2450/2012.0060-12. [Epub ahead of print]
ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia.
Spiezia L, Campello E, Bon M, Tison T, Milan M, Simioni P, Prandoni P.
Although having a non-O blood type is now regarded as a risk factor for venous thromboembolism, the strength of this association is poorly defined, as is its interaction with inherited thrombophilia.
MATERIALS AND METHODS:The prevalence of non-O blood group and inherited thrombophilia (deficiencies of natural anticoagulants, factor V Leiden and prothrombin G20210A mutation) was assessed in a series of 712 consecutive patients with proximal deep vein thrombosis (DVT) of the lower limbs who were referred to our Institution between 2004 and 2010, and in 712 age- and gender-matched healthy volunteers. Odds ratios (OR) of DVT and their 95% confidence intervals (CI) were computed for non-O group and thrombophilia, both separately and in combination.
RESULTS:A non-O blood group was present in 492 cases and 358 controls (OR 2.21; 95% CI, 1.78 to 2.75). A thrombophilic abnormality was present in 237 cases and 105 controls (OR 2.82; 2.18 to 3.66). The combination of non-O group and thrombophilia was present in 152 cases and 51 controls (OR 7.06; 4.85 to 10.28).
DISCUSSION:Having a non-O blood group is associated with an increased risk of proximal DVT of the lower limbs with or without pulmonary embolism. The addition of inherited thrombophilia increases the thrombotic risk conferred by non-O group alone by almost 3-fold.