Buerger’s disease - What progress has been made in the last decade in salvaging the ischemic limbs of the young smokers with TAO?

In the past we often considered minor or major amputations in ischemic legs of young smokers when the medical and surgical therapies failed to relieve the severe pain associated with non healing ulcers or gangrene. But now after the introduction of Prostaglandin E-1 infusions therapies for the below knee non re-constructable vascular disease we are able to relieve the rest pain and help in healing the ischemic ulcers with more certainty. We are following the patients for 6 months and so we are able to guide the patients and confirm their limb salvage for a long time. The cost of therapies has also been spread over a period of 6 months and so their affordability and compliance is surprisingly very good in these ill nourished patients. We have also been looking for features of systemic inflammatory responses (SIRS) in these patients who are groaning with ischemic rest pain. Low dose steroid therapy and immune modulators have been helpful in TAO patients with SIRS like features when added to the PGE-1 therapy. We did not use epidural analgesia for the relief of rest pain in the recent past when we are using the PGE1 + LDS + IMT. We do not routinely consider the wound swab cultures from the ulcers or dry gangrene with minimal wetting of the surface. These patients do not tolerate dressing over their feet and they loosely wrap gauze bandage over their ischemic ulcers, gangrene feet. Few patients are not able to abstain from smoking though they may reduce the number of cigarettes. Yet, we have noted the good response with the PGE1 + LDS + IMT in these people. We have not done major amputations in the last year in these patients. Only gangrenous toes which are failing to separate and fall off, on the request of the patients we consider surgical separation after completion of the PGE1 + LDS + IMT course.

Happy New year 2015

to you

with best wishes.

Pinjala R K

Pseudomonas aeruginosa - Touch or taste? which one should it like before infecting us?

Pseudomonas aeruginosa
Pseudomonas aeruginosa is a common bacterium that leads to a variety of diseases in plants, animals, and humans and is relatively impervious to antibiotics. For years, scientists remained perplexed at how a single species of bacteria was able to infect such a wide array of hosts. Typically, bacteria use chemical signals to “taste” their environment; if bacteria detect they are in a good place for their survival, they will infect and thrive. Bacteria also rely on “quorum sensing,” the ability to determine how many of their kind are present before mounting an infection. Researchers at Princeton have discovered for the first time that Pseudomonas aeruginosa relies on touch (not taste) for infection. It doesn’t necessarily matter if they’re “tasting” the right environment or not; it just matters if they are on any environment at all. Once attached to any host surface, the bacteria initiate quorum sensing before rapidly overwhelming nearby organisms, including the host.
Pinjala R K