Intermittent claudication

Intermittent claudication is a common condition affecting over 5% of the population over the age of 65 years.
Patients exhibit limited walking ability, but over recent years a number of studies have identified that claudication is also associated with significant impairments in overall physical function,1 including walking speed, lower limb strength, and balance. There is strong evidence that higher levels of daily activity in claudicants reduces functional decline and associated morbidity/mortality in the mid to long term. Furthermore, there is increasing evidence that claudicants have associated balance impairments that may predispose to an increased risk of falling and its associated physical and socio-economic consequences.

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication - Risha Arun Gohil, et al
Objective: The aim of this study was to identify whether revascularization by percutaneous transluminal angioplasty (PTA) for patients with intermittent claudication improved measures of functional performance including balance.
Methods: A prospective observational study was performed at a single tertiary vascular center. Patients with symptomatic intermittent claudication (Rutherford grades 1-3) were recruited to the study. Participants were assessed at baseline (pre-PTA) and then, and 12 months post-PTA for markers of (1) lower limb ischemia (treadmill walking distances and ankle-brachial pressure index), (2) physical function (6-minute walk, Timed Up and Go, and chair stand time), (3) balance impairment using computerized dynamic posturography with the Sensory Organization Test, and (4) quality of life (VascuQoL and Short Form Health Survey [SF-36]).
Results: Forty-three participants underwent PTA. Over 12 months, a significant improvement was demonstrated in initial (P = .04) and maximum treadmill walking distance (P = .019). Physical functional ability improved across all outcome measures (P < .02), and some domains of both generic (P < .03) and disease-specific quality of life (P < .01). No significant improvement in balance was demonstrated by the Sensory Organization Test (P = .24).
Conclusions: Balance impairment is common in claudicants and does not improve with revascularization. Further research regarding effective treatment of balance impairment is required in this specific group of patients.

Journal of Vascular Surgery Volume 58, Issue 6, December 2013, Pages 1533–1539

Medial arterial calcification in the feet of diabetic patients

Diabetologia. 1993 Jul;36(7):615-21.

Medial arterial calcification in the feet of diabetic patients and matched non-diabetic control subjects.

Young MJ, Adams JE, Anderson GF, Boulton AJ, Cavanagh PR.

Author information

Abstract

The prevalence and distribution of medial arterial calcification was assessed in the feet of four subject groups; 54 neuropathic diabetic patients with previous foot ulceration (U), median age 60.5 (50.5-67 interquartile range) years, duration of diabetes 19.5 (9.9-29.9) years; 40 neuropathic diabetic patients without a foot ulcer history (N), age 68 (62-73) years, duration of diabetes 14.0 (8.0-28.0) years; 43 non-neuropathic diabetic patients (NN), age 60.5 (52-68.5) years, duration of diabetes 14.0 (8.0-28.0) years and 50 non-diabetic control subjects, age 62.5 (53.7-70) years. A single radiologist graded medial arterial calcification as absent, mild or severe, at the ankle, hind-foot, mid-foot, metatarsals and toes on standardised plain lateral and antero-posterior foot radiographs taken by a single radiographer. Diabetes history, vibration perception threshold, ankle systolic pressure and serum creatinine were also assessed. 

Medial arterial calcification was significantly greater (total score 18 [3-31]) in neuropathic diabetic patients with previous ulceration (U vs N p < 0.01, U vs NN p < 0.001). 

Non-neuropathic diabetic patients did not have significantly higher arterial calcification scores than age-matched non-diabetic control subjects. 

Medial arterial calcification correlated with vibration perception threshold (r = 0.35), duration of diabetes (r = 0.32) and serum creatinine (r = 0.41), (all p < 0.01). 

Logistic regression models showed vibration perception and duration of diabetes to predict the probability of any calcification. Serum creatinine level was added to predict severe calcification.

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication

Intermittent claudication is a common condition affecting over 5% of the population over the age of 65 years. Patients exhibit limited walking ability, but over recent years a number of studies have identified that claudication is also associated with significant impairments in overall physical function,including walking speed,  lower limb strength, and balance. There is strong evidence that higher levels of daily activity in claudicants reduces functional decline and associated morbidity/mortality in the mid to long term. Furthermore, there is increasing evidence that claudicants have associated balance impairments that may predispose to an increased risk of falling and its associated physical and socio-economic consequences.

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication  Risha Arun Gohil, et al  Objective: The aim of this study was to identify whether revascularization by percutaneous transluminal angioplasty (PTA) for patients with intermittent claudication improved measures of functional performance including balance. Methods: A prospective observational study was performed at a single tertiary vascular center. Patients with symptomatic intermittent claudication (Rutherford grades 1-3) were recruited to the study. Participants were assessed at baseline (pre-PTA) and then, and 12 months post-PTA for markers of (1) lower limb ischemia (treadmill walking distances and ankle-brachial pressure index), (2) physical function (6-minute walk, Timed Up and Go, and chair stand time), (3) balance impairment using computerized dynamic posturography with the Sensory Organization Test, and (4) quality of life (VascuQoL and Short Form Health Survey [SF-36]). Results: Forty-three participants underwent PTA. Over 12 months, a significant improvement was demonstrated in initial (P = .04) and maximum treadmill walking distance (P = .019). Physical functional ability improved across all outcome measures (P < .02), and some domains of both generic (P < .03) and disease-specific quality of life (P < .01). No significant improvement in balance was demonstrated by the Sensory Organization Test (P = .24). Conclusions: Balance impairment is common in claudicants and does not improve with revascularization. Further research regarding effective treatment of balance impairment is required in this specific group of patients.

Sleep and Quality of Life

“Appetite and Sleep” are very important to enjoy the quality of life. The sleeping patterns are variable depending on the physical condition and different kinds of diseases.  

Recently a new study showed that poor sleep quality is strongly associated with mood disturbance and lower quality of life among people with extreme obesity. The study involved 270 patients with a mean body mass index (BMI) of 47.0 kg/m2 who were consecutively enrolled in a regional specialist weight management service. They had a mean age of 43 years. Sleep disturbance, daytime sleepiness, mood and quality of life were assessed using standardized questionnaires. The medical personnel working on night duties in busy centers are usually missing that necessary sleep. In a big hospital when there shortage of staff it is still worse as they may be doing continuous duties for 24 to 48 hours (weekend).

Some time back people were concerned about the decisions one would make in absence of sleep for saving the lives of critically ill patients. One can also see the mood changes in people deprived of adequate sleep which can affect the interpersonal relationships. The results of this recent study showed that 74.8 percent of participants were poor sleepers, and their mean self-reported sleep duration was only six hours and 20 minutes. Fifty-two percent of study subjects were anxious, and 43 percent were depressed. After controlling for age, sex, hypertension, diabetes, and obstructive sleep apnea, sleep quality and daytime sleepiness were significantly associated with mood disturbance and quality of life impairment.

"There was a clear association between the sleep problems such as short sleep duration and the psychological disorders and with quality of life," said Dr. G. Neil Thomas, lead supervisor, study methodology lead and reader in epidemiology at the Department of Public Health, Epidemiology and Biostatistics at the University of Birmingham in the United Kingdom. "These associations remained significant even after adjusting for a range of potential confounders." According to the authors, the potential role of sleep in the health and well-being of individuals with severe obesity is underappreciated. Although the cross-sectional design of the study did not allow for an examination of causality, the results suggest that the early detection of disturbed sleep could prevent the potential development and perpetuation of psychological problems among people with extreme obesity. "Despite the very high levels of problems in these patients, those involved with their care usually don't ask about sleep problems and often pay little heed to the psychological issues underlying the obesity," said Thomas. "The focus is often on treating the obesity and its consequences, such as diet and exercise interventions, rather than addressing its underlying cause, which may be psychological in nature, such as an unhappy marriage or job stress."

According to the Centers for Disease Control and Prevention, 35.7 percent of U.S. adults are obese with a BMI of 30 or higher. The CDC estimates that the annual medical cost of obesity in the U.S. was $147 billion in 2008 dollars. Obesity is a huge burden on the society in developed countries; it is soon to be seen in the other countries too. We are already seeing the advertisements on the road side by the people providing the bariatric surgery for the obese people.

In mammals and birds, sleep is divided into two broad types: rapid eye movement (REM sleep) and non-rapid eye movement (NREM or non-REM sleep). Each type has a distinct set of associated physiological and neurological features. The American Academy of Sleep Medicine (AASM) further divides NREM into three stages: N1, N2, and N3, the last of which is also called delta sleep or slow-wave sleep.

Academic Paper publications:

1. Masson's Hemangioma of Proximal Radial Artery - Tumour like vascular lesions are rare. Here we report a rare case of tumor like vascular lesion from the radial artery. A pulsatile swelling in the forearm is usually diagnosed as a case of Aneurysm, AV fistul... Ramakrishna Pinjala in Indian Journal of Surgery (2012)

2. Thrombophilia – How Far and How Much to Investigate?- Thrombohemorrhagic balance is maintained by complicated interactions between the coagulation and fibrinolytic system, platelets, and the vessel wall. Dr. Virchow provided approach for investigating and managin...

R. K. Pinjala, L. R. C. Reddy, R. P. Nihar, G. V. A. Praveen… in Indian Journal of Surgery (2012)      

3. Leiomyosarcoma of the Inferior Vena Cava:Segment II- R. Pinjala  Received 20 November 2012; accepted 24 April 2013. published online 10 June 2013. PII: S1533-3167(13)00019-8 doi :10.1016/j.ejvsextra. 2013.04.002 © 2013 European Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

4. Venous thromboembolism risk & prophylaxis in the acute hospital ... Ramakrishna Pinjala on behalf of all ENDORSE-India investigators*. Department of Vascular Surgery, Nizam's Institute of Medical Sciences, Hyderabad, India ...www.icmr.nic.in/ijmr/2012/july/0709.pdf - Cached - Similar

5. Retrospective evidence for clinical validity of expanded genetic model in warfarin dose optimization in a South Indian population Addepalli Pavani, Shaik Mohammad Naushad, Ramesh C Mishra, Amaresh Rao Malempati, Ramakrishna Pinjala, Takallapally Ramesh Kumar, Vijay Kumar Kutala  Pharmacogenomics, June 2012, Vol. 13, No. 8, Pages 869-878. 6. Optimization of warfarin dose by population-specific pharmacogenomic algorithm. Pavani A, Naushad SM, Rupasree Y, Kumar TR, Malempati AR, Pinjala RK, Mishra RC, Kutala VK. Source Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India. Pharmacogenomics J. 2012 Aug;12(4):306-11. doi: 10.1038/tpj.2011.4. Epub 2011 Mar 1. Important functions During this year 2012-13: Elected President of the Vascular Society of India Received –  Fellowship from the Vascular society of India Promoted as Senior professor – in Nizam’s Institute of Medical Sciences Academic Associate Dean of the NIMS – Appointed Examiner for the National DNB-vascular surgery examination Examiner for MCh-Vascular surgery examination Theory Paper setting for the DNB and MCh vascular surgery examinations MCQs – for the entrance examinations for the vascular surgery MCh and DNB courses MCI – inspector  for examining the facilities at the centres to start the MCh vascular surgery. Attended the National and international conferences in India. Organizing chairman for the Annual meetings of Day care surgery, Diabetic foot society of India – Annual conferences in Hyderabad. Delivered Lectures on Deep vein thrombosis, Triple Combination therapy in Hypertension, Diabetic dysvascular foot, High dose statin therapy in the prevention of cardiovascular mortality, ischemia reperfusion syndrome, Diabetic foot infections, Newer anticoagulants.

Excess dietary sodium is a major public health problem worldwide

High Salt intake is common in some parts of the world. Excessive carbohydrate intake can lead to Diabetes and excessive salt intake can lead to the hypertension and the associated complications. Many drugs and formulations contain sodium and it was observed that that can be harmful too.

Exposure to sodium-containing formulations of effervescent, dispersible, and soluble medicines was associated with significantly increased odds of adverse cardiovascular events compared with standard formulations of those same drugs. Sodium-containing formulations should be prescribed with caution only if the perceived benefits outweigh these risks.

Excess dietary sodium is a major public health problem worldwide. In response to a 2010 report by the Institute of Medicine, the National Salt Reduction Initiative (NSRI) was established with a goal to reduce dietary sodium consumption in the United States by 20% in five years. Reducing sodium intake in the US to the recommended 2.3 g/day (100 mmol/L or one teaspoonful) could prevent 11 million cases of hypertension, save $18bn (£11bn, €13bn) healthcare dollars, and gain 312 000 quality adjusted life years (QALYs) valued at $32bn annually. In the United Kingdom, the Food Standards Agency also launched a campaign in 20023 to reduce salt intake in the estimated 26 million people in the UK who have high dietary sodium intake. It has been estimated that a 3 g/day reduction in salt (1.2 g/day reduction in sodium) could prevent 30 000 cardiovascular events and save the National Health Service (NHS) at least £40m/year (€48m, $64m).
The dispersible and effervescent formulations of paracetamol 500 mg, however, can contain 18.6 mmol and 16.9 mmol of sodium in each tablet, respectively, and therefore the maximum daily dose of eight tablets/day results in the ingestion of 148.8 mmol and 135.2 mmol of sodium, respectively. This exceeds the recommended total daily allowance of sodium for one drug alone. Added to a typical Western diet, these drugs could result in high sodium intake. Curiously, unlike foods, pharmaceutical manufacturers are not placed under any restrictions or obligations with regards to sodium content or labeling of these sodium-containing formulations.
Beware of Tablets with High sodium content especially in patients where you are restricting salt intake !!!

Varicose GSV and catheter directed foam sclerotherapy

In India, surgical therapies or endovenous ablative therapies for varicose veins are going to be more expensive than the sclerotherapy under local anesthesia. It is possible to treat more people if the sclerotherapy results are improved further with less primary or secondary failures. Sclerotherapy for the axial veins (GSV) is considered to be inadequate as they have a larger lumen and it is difficult to decide the concentration of the sclerosant solution prior to injection. Catheter directed foam sclerotherapy seems to be good in these patients to maintain the appropriate contact between the foam and venous endothelium. Some times we feel that the vein lumen reduction can help us to achieve better results. I noted a study in which vein (GSV) diameter was reduced by perivenous tumescent local anesthesia before the infection of foam sclerosant in the through a catheter. 8ml of 2% foam was used for occluding the GSV. Patients were followed 1, 6, 12 months period. No benefit could be found using additional TA to reduce the vein diameter before the treatment.

Eur J Vasc Endovasc Surg. 2013 Oct 30. pii: S1078-5884(13)00649-7. doi: 10.1016/j.ejvs.2013.10.017. [Epub ahead of print]

Catheter-directed Foam Sclerotherapy of Great Saphenous Veins in Combination with Pre-treatment Reduction of the Diameter Employing the Principals of Perivenous Tumescent Local Anesthesia.

Devereux N, Recke AL, Westermann L, Recke A, Kahle B.

Source

Department of Dermatology, University of Schleswig-Holstein, Campus Luebeck, Germany.

Abstract

OBJECTIVES:

The aim of this study was to evaluate occlusion rates of great saphenous veins (GSV) with a diameter between 5-10 mm that received a pre-treatment size reduction via perivenous tumescent application (TA) followed by catheter-directed foam sclerotherapy (CDFS).

METHODS:

A prospective blinded randomized clinical trial comparing the occlusion rates of GSV at 1-, 6-, and 12-month follow-up. Fifty patients were included and randomized into two groups. CDFS was performed accessing the GSV at knee level and applying 8 mL of 2% polidocanol-foam (EasyFoam) while the catheter was withdrawn. Strictly perivenous TA was performed in group 1 before applying the sclerosant agent. Occlusion rates and clinical scores were assessed by blinded examiners.

RESULTS:

After 12 months in group 1 full occlusion was achieved in 73.9%, partial occlusion in 8.7%, and 17.4% were classified as treatment failure. In group 2, 75% of the targeted GSV were fully occluded, 20% were partially occluded, and 5% were diagnosed as treatment failure. Both groups showed a significant reduction of the vein diameter. Patient's tolerance and satisfaction with the treatment was high in both groups.

CONCLUSION:

No benefit could be found using additional TA to reduce the vein diameter before the treatment.

Bacteria killing virus – this can be helpful to fight some of the superbugs!

http://www.medicalnewstoday.com/articles/267573.php

Bacteria killing virus – this can be helpful to fight some of the superbugs!

We are constantly looking for the ways and means to fight the superbugs. Now there seems to be a potential new victory in the war against antibiotic-resistant "superbugs" lies in the discovery of specific viruses that eat bacteria - called bacteriophages. Researchers in the UK have isolated certain phages, which have been shown to target the infectious hospital bug Clostridium difficile. C. diff, as the superbug is known, is responsible for 250,000 infections in the US each year and results in 14,000 deaths, the researchers say. Causing excess medical costs of $1 billion each year, finding a solution to this problem is one of both medical and economic importance. Dr. Martha Clokie, from the University of Leicester's Department of Infection, Immunity and Infection, has been studying how naturally occurring bacteriophages - which means "eaters of bacteria" - could serve as an alternative to antibiotics. Though Dr. Clokie gives credit to the important role antibiotics have played in saving lives, she says new treatments are needed: "Less than a century following their discovery, the future impact of antibiotics is dwindling at a pace that no one anticipated, with more and more bacteria out-smarting and 'out-evolving' these miracle drugs. This has re-energized the search for new treatments."Unlike antibiotics, Dr. Clokie says phages "are specific in what they kill," noting that they usually infect only one specific species or strain of bacteria.By injecting their DNA into the bacterium, she notes that phages then replicate and cause the bacterial cell to "burst open." Once the dead bacterium is opened, the phages can then repeat the process on other host cells. Maintaining gut bacteria balance: What is so remarkable about the research team's finding is that they were able to isolate and characterize 26 distinct phages - the biggest set of C. diff phages that are currently known.These phages infect strains of C. diff that are "clinically relevant," and they have been proven to be effective against 90% of the strains currently seen in the UK. Dr. Clokie says:"C. diff bacteria primarily affect our digestive system. Whilst relatively innocuous in individuals with a healthy gut flora, they pose a serious threat when our natural digestive environment is disrupted or depleted, such as after chronic antibiotic use." She notes that the ability of phages to only infect and kill a specific type of bacteria is "particularly important" when dealing with C. diff infections, because keeping the balance of gut bacteria "greatly reduces the chance of relapse."Clinical trials soon, Dr. Clokie's phages have been licensed by a US biopharmaceutical company called AmpliPhi Biosciences Corporation, and together, they aim to have a mixture of C. diff phages ready for phase I and II clinical trials in the near future. The company, which has developed phage-based therapeutics, is funding further development and testing of these phages. Dr. Clokie and colleagues from the University of Leicester will work with scientists from the University of Glasgow in Scotland to analyze the efficacy of the phages in treating infections. The work has been predominantly funded by the Medical Research Council (MRC), and Dr. Des Walsh, head of Infections and Immunity at the MRC, says that Dr. Clokie "has established an impressive collection of phage viruses and has developed strong partnerships to translate her research into potential new treatments for Clostridium difficile infection."

"Ultimately," says Dr. Clokie, "I hope this will pave the way for a greater use of bacteriophages in the wider, global fight against antibiotic-resistant bacteria." When asked how long until patients might begin to see benefits from her research, Dr. Clokie told  "If all goes well," she added, "we could see a product in 5-10 years."

Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment

Intracranial stenosis before and after angioplasty

Vascular surgeons are treating the extracranial carotid artery stenosis, neurosurgeons and interventionists are treating the intracranial stenotic lesions to reduce the cerebral ischemia which can lead to stroke. In india, intra cranial lesions are more common than the extra cranial artery lesions. So, the number of endarterectomies performed are less in India and few centers are providing these services. The recent developments in proving best medical therapies certainly reduced the risk of stoke in hypertensive patients, Diabetic people.
Intracranial atherosclerosis is one of the most common causes of stroke worldwide and is associated with a high risk of recurrent stroke. New therapeutic approaches to treat this high-risk disease include dual antiplatelet treatment, intensive management of risk factors, and endovascular therapy. Early data from randomised trials indicate that aggressive medical therapy is better than stenting for prevention of recurrent stroke in high-risk patients with atherosclerotic stenosis of a major intracranial artery. Nevertheless, there are subgroups of patients who remain at high risk of stroke despite aggressive medical therapy. Further research is needed to identify these high-risk subgroups and to develop more effective treatments. Non-invasive vascular imaging methods that could be used to identify high-risk patients include fractional flow on magnetic resonance angiography (MRA), quantitative MRA, and high-resolution MRI of the atherosclerotic plaque. Alternative therapies to consider for future clinical trials include angioplasty alone, indirect surgical bypass procedures, ischaemic preconditioning, and new anticoagulants (direct thrombin or Xa inhibitors).
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70195-9/abstract
 

Pulmonary embolism after endovenous thermal ablation of the saphenous vein.

Semin Vasc Surg. 2013 Mar;26(1):14-22. 

Pulmonary embolism after endovenous thermal ablation of the saphenous vein.

Rosales-Velderrain A, Gloviczki P, Said SM, Hernandez MT, Canton LG, Kalra M.

Division of Vascular and Endovascular Surgery, Mayo Clinic, 200 1(st) Street, SW, Rochester, MN 55905.

Pulmonary embolism (PE) after venous procedures is fortunately rare. Our goal was to analyze the data of patients who developed PE after endovenous thermal ablation and phlebectomy for varicose veins and to review the literature on this subject. We report on three patients who developed PE after radiofrequency ablation of the great saphenous vein and mini phlebectomy for symptomatic primary lower-extremity varicose veins. Early postoperative duplex scans confirmed successful closure of the great saphenous vein in all. One patient presented with chest pain and dyspnea, one with blood-tinged sputum, and the third with symptoms of saphenous thrombophlebitis. Two patients had PE from the saphenous vein thrombus and the third had gastrocnemius vein thrombosis extending into the popliteal vein. One had previous deep vein thrombosis. Computed tomography of the chest confirmed PE in all. Two patients were treated with anticoagulation, but the third patient with small PE declined such treatment. One patient underwent temporary inferior vena cava filter placement because of recurrent PE. In conclusion, PE is very rare but it can occur after endovenous thermal ablation of lower-extremity varicose veins. Selective thrombosis prophylaxis and preoperative counseling of the patients about signs and symptoms of deep vein thrombosis and PE are warranted for early recognition and rapid treatment. 

Is it difficult to choose the cost effective mode of treatment for aortic aneurysms after the introduction of the endovascular therapies for the aneurysms?

The Cost of open and endovascular repair of the aortic aneurysms is comparable?

It is generally felt that the Endovascular vascular repairs of the aortic aneurysms is more expensive than the open repair in India. The duration of the hospital stay and other services are considered to be less expensive in India than in the other countries. There are some studies published in the EJVES and JVS saying that the Endovascular repair may be better than open in terms cost saving!  It may be surprising to some of us in India. 

The cost of the Endoprosthesis is more than Rs. 3,50,00 to 10,00,000 depending on the number of devices and hard ware used during the procedures. The multinational companies are trying to provide the necessary supports by extending concessions in some cases. 

In many Governments hospitals the surgeons don’t have privileges to enter the cath labs and at the same these procedures are not supported financially in government hospitals. So, majority of the cath lab procedures are done in private sector in our country. There are few govt. general hospitals performing these procedures maintaining a balance between the cost and the outcomes. We strongly feel that the Govt. should propose to establish the cath labs accessible to all the doctors treating the patients through endovascular methods. There is also need for the hybrid operation theatres to facilitate the minimally invasive operations to reduce the morbidity and mortality.  

VAC study group from USA says that Endovascular repair is a cost-effective alternative to open repair in the US VA healthcare system for at least the first two years Eur J Vasc Endovasc Surg. 2012 Dec;44(6):543-8. Stroupe KT et al say that In a multicenter randomized trial, endovascular AAA repair resulted in lower cost and better survival than open repair after the initial hospitalization for repair; but after 2 years, survival, quality of life, and costs were not significantly different between the two treatments. J Vasc Surg. 2012 Oct;56(4):901-9. Routine use of endovascular repair in patients also eligible for open repair does not result in a QALY gain at 1 year postoperatively, provides only a marginal overall survival benefit, and is associated with a substantial, if not prohibitive, increase in costs. Prinssen M et al J Vasc Surg. 2007 Nov;46(5):883-890.

PGE-1 in addition to the standard care (statins) to prevent the renal injury after coronary angiography - is good ?

Can we give PGE-1 in addition to the standard care (statins) to prevent the renal injury after coronary angiography in mild to moderate CKD patients?

Prostaglandin E-1 is used to relieve the rest pain, heal ulcers in patients with non reconstructable critical ischemia. Prostaglandin E-1 is known to produce micro vasodilation and improve the metabolism of the tissues to relieve the symptoms and heal ulcers in ischemic patients. It has to be intravenously to get these benefits. Oral Prostaglandin E1 did not show similar benefits in these patients. Pulmonary hypertension in cardiac patients is also relieved by the PGE-1 in the perioperative periods. Contrast induced nephropathy (CIN) is a known complication after angiograms. We avoid this complication (CIN) - by properly hydrating the patients and giving N-acetyl cysteine. Coronary angiogram in mild to moderate CKD patients is associated with additional risk and there are no definite measures which can reduce the risk of worsening of renal failure. This has given opportunity for the Liu WJ et al from Shanghai to study benefits of adding PGE-1 to Statins to reduce the incidence of CIN in patients undergoing the coronary angiogram. They published their results recently and they are favourable.

In their study, a total of 156 consecutive patients with mild to moderate renal failure who underwent coronary angiography were enrolled in the study, and randomly categorized into two groups. In the statins group, 80 patients were treated with statins before and after coronary angiography. In the alprostadil plus statins group, 76 patients were treated with statins and alprostadil before and after coronary angiography. Serum creatinine (SCr), serum cystatin (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) were detected after administration of contrast media, and adverse events were evaluated within six months. Inj. PGE-1 is given for 7 days (20mcg/day) started one day prior to coronary angiogram. In both groups, the SCr, CysC and NGAL significantly increased after coronary angiography and peaked at 48, 24 and 6 hours, respectively. SCr, CysC and NGAL were significantly lower in the alprostadil plus statins group than in the statins group (P < 0.05).

The incidence of CIN in the alprostadil plus statins group was slightly lower than in the statins group. The incidence of adverse events within six months in the alprostadil plus statins group was significantly lower than in the statins group (P = 0.034). They concluded by saying that Intravenous alprostadil in combination with oral statins is superior to statins alone for protecting renal function in patients with mild to moderate renal dysfunction who undergo coronary angiography, and can reduce the incidence of adverse events seen within six months.

Fig: Kaplan-Meier method was used to analyze the timing of adverse events during follow-up period. The incidence of adverse events was lower in the alprostadil plus statins group (group 2) than in the statins group (group 1) (P=0.034).

Chin Med J (Engl). 2013 Sep;126(18):3475-80. Renoprotective effect of alprostadil in combination with statins in patients with mild to moderate renal failure undergoing coronary angiography.Liu WJ, Zhang BC, Guo R, Wei YD, Li WM, Xu YW. Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Atrial fibrillation and hypertension - increase the risk of Stroke

It is more important to recognize the atrial fibrillation and treat it  to prevent the stroke related morbidity.AF increases the risk of stroke. The degree of increase can be substantial, depending on the presence of additional risk factors (such as high blood pressure). Atrial fibrillation may be treated with medications to either slow the heart rate to a normal range ("rate control") or revert the heart rhythm to normal ("rhythm control"). Synchronized electrical cardioversion can be used to convert AF to a normal heart rhythm. Surgical and catheter-based ablation may be used to prevent recurrence of AF in certain individuals. Depending on the risk of stroke and systemic embolism, people with AF may use anticoagulants such as warfarin, which substantially reduces the risk but may increase the risk of major bleeding, mainly in geriatric patients. The prevalence of AF in a population increases with age, with 8% of people over 80 having AF. Chronic AF leads to a small increase in the risk of death.

Four types of Atrial fibrillations!!

All atrial fibrillation patients are initially in the category called first detected AF. These patients may or may not have had previous undetected episodes. If a first detected episode self-terminates in less than 7 days and then another episode begins later on, the case has moved into the category of paroxysmal AF. Although patients in this category have episodes lasting up to 7 days, in most cases of paroxysmal AF the episodes will self-terminate in less than 24 hours. If instead the episode lasts for more than 7 days, it is unlikely to self-terminate,^[2] and it is called persistent AF. In this case, the episode may be still terminated by cardioversion. If cardioversion is unsuccessful or it is not attempted, and the episode is ongoing for a long time (e.g., a year or more), the patient's AF is called permanent. Episodes that last less than 30 seconds are not considered in this classification system. Also, this system does not apply to cases where the AF is a secondary condition that occurs in the setting of a primary condition that may be the cause of the AF.

Can Gene modification occur with exercise to fight obesity and Type 2 diabetes? May be or may be not!

Exercise on daily basis seems to be helpful in many ways. But we still can’t find time to do the regular exercise or many of us take an excuse for not going for a walk or exercise or play a game to produce sweat. Exercise is advised to protect the heart, reduce weight, prevent and control diabetes, hypertension. Many people ask us for an alternative to 30 minute exercise because they feel that they are wasting another 1 hour they are needing prepare and get ready to go for work in the morning after exercises. Some say with a smiling face when will the doctors find a tablet which is equal to walking exercise and give the same benefits of walking? Some others feel that they can not walk because of their physical disabilities or leg pains and they are seriously looking for the alternatives to the regular walking exercise.

In the recent it was found that exercise actually works on methylation of the DNA and chemically changes the DNA of the fat tissues in the body and generates the benefits which we are noticing. The researchers found 24 sites located close to 18 of the candidate genes for obesity with a difference in DNA methylation in adipose tissue in response to the exercise intervention. Additionally, two of those genes (CPEB4 and SDCCAG8) showed significant changes in mRNA expression after exercise (meaning that the activity of these particular genes was significantly changed by exercise).

Among the T2D candidate genes, 45 sites in 21 different genes were differentially methylated in fat tissue before versus after exercise. Of note, 10 of these sites mapped to KCNQ1 and 6 sites mapped to TCF7L2-important since TCF7L2 is the gene showing the highest genetic association with type 2 diabetes. A simultaneous change in mRNA expression was seen for four of the T2D candidate genes where mRNA expression decreased while DNA methylation increased in adipose tissue in response to exercise, meaning that again, the activity of these particular genes was significantly changed by exercise. The study is by Dr Tina Rönn, Lund University, Malmö, Sweden. She adds: "Since we also observed DNA methylation changes in genes important for fat metabolism, which indicates increased fat uptake in response to exercise, these genes could potentially be a target for future drugs."

May be one day, there may be a pill for some one who can not do the exercise to get the benefits equal to that exercise. Very interesting too!! Let us hope so !  Let those also get the benefit of exercise without exercise.

The Beta3-Adrenergic Receptor Gene: The Beta3-adrenergic receptor gene makes a protein in fat cells that is involved in determining how much fuel your body burns when you are resting. A mutation in this gene slows down how quickly a person burns fat — increasing their tendency to be obese. One specific mutation in this gene, called TRP64ARG, is almost four times more common in Pima Indians than in people of European descent, and is one and a half times more common in people of African or Mexican descent. The prevalence of the TRP64ARG gene mutation in these populations probably accounts at least in part for why these ethnic groups have a higher rate of Type 2 diabetes. The genetics of Type 2 diabetes is complicated, with many different genes influencing a person's risk. Because of this array of genes, Type 2 diabetes is not inherited in a clearly dominant or recessive manner. Instead, a person may have one gene that increases their risk and other genes that decrease risk. Together, these genes, along with environmental factors, determine a person's overall risk for developing diabetes. With so many variables to consider, the medical community is a long way from a genetic test for Type 2 diabetes. Although there is no genetic test for Type 2 diabetes, the American Diabetes Association recommends screening for diabetes onset every three years if you have diabetes in the family. Doctors screen for diabetes onset using a fasting glucose test or glucose tolerance test, which tells doctors if your blood glucose levels are unusually high.

World heart day 2013 - September 29th

Researchers from the World Heart Federation say that in order to prevent the risk of heart disease and stroke, we need to raise awareness around risk factors, such as physical inactivity, unhealthy eating, obesity and tobacco use. They say that regular moderate exercise, including walking, has many heart benefits.  Walking, they note, is one of the most accessible and least expensive ways to achieve the recommended physical activity to prevent heart diseases.

By walking 30 minutes a day, 5 days a week, the World Heart Federation says people can increase their life expectancy by up to 3 years, reduce the risk of cardiovascular disorder by as much as 11%, and burn more fat than jogging.

As World Heart Federation President Dr. Srinath Reddy says, "Your feet can carry your heart very far in life." According to the organization, if people do not take action to live heart-healthy lives, cardiovascular disease will continue to be the leading cause of death worldwide, causing an estimated 23.6 million deaths each year by 2030.

The survey, conducted by the World Heart Federation, focused on walking because, according to the organization, it is one of the simplest things we can do to protect our heart health. Six countries - Brazil, China, India, Spain, UK and US - participated in the survey, which was conducted by YouGov and yielded a total of 7,367 respondents over 18 years of age in August 2013. The survey asked two questions: how much time do you spend walking at a slow pace each day and how much time at a fast pace?

Results from the study show that: In the US and UK, one in three adults do not know how much they walk each day, compared with only one in six adults in India. 


In the six countries surveyed, 55% of respondents who reported times walk briskly for less than 30 minutes each day. In the US and UK, only about 33% of adults do the recommended 30 minutes of brisk walking each day, compared with about 50% of adults in Brazil and India. Dr. Kathryn Taubert, chief science officer from the World Heart Federation, says: "Awareness is the first step to a healthy heart. Paying attention to how much we walk should be as simple as watching what we eat. On World Heart Day, we are urging people to take action to protect their hearts."

Comparison of coronary artery bypass surgery and percutaneous coronary intervention in patients with diabetes: a meta-analysis of randomised controlled trials

People with diabetes have a 30 per cent less chance of dying if they undergo coronary artery bypass surgery rather than opening the artery through angioplasty and inserting a stent, a new study has found.

Comparison of coronary artery bypass surgery and percutaneous coronary intervention in patients with diabetes: a meta-analysis of randomised controlled trials

Dr Subodh Verma MD a e g , Michael E Farkouh MD e f h, Bobby Yanagawa MD g, David H Fitchett MD b e h, Muhammad R Ahsan MD a, Prof Marc Ruel MD l, Sachin Sud MD h m, Milan Gupta MD a e h n, Shantanu Singh k, Nandini Gupta MD a l, Asim N Cheema MD b e h, Prof Lawrence A Leiter MD c e h i, Paul W M Fedak MD o, Hwee Teoh PhD a c e, David A Latter MD a e g, Prof Valentin Fuster MD p q, Dr Jan O Friedrich MD d e h j

The choice between coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI) for revascularisation in patients with diabetes and multivessel coronary artery disease, who account for 25% of revascularisation procedures, is much debated. We aimed to assess whether all-cause mortality differed between patients with diabetes who had CABG or PCI by doing a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing CABG with PCI in the modern stent era.

We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from Jan 1, 1980, to March 12, 2013, for studies reported in English. Eligible studies were those in which investigators enrolled adult patients with diabetes and multivessel coronary artery disease, randomised them to CABG (with arterial conduits in at least 80% of participants) or PCI (with stents in at least 80% of participants), and reported outcomes separately in patients with diabetes, with a minimum of 12 months of follow-up. We used random-effects models to calculate risk ratios (RR) and 95% CIs for pooled data. We assessed heterogeneity using I2. The primary outcome was all-cause mortality in patients with diabetes who had CABG compared with those who had PCI at 5-year (or longest) follow-up.

Findings

The initial search strategy identified 3414 citations, of which eight trials were eligible. These eight trials included 7468 participants, of whom 3612 had diabetes. Four of the RCTs used bare metal stents (BMS; ERACI II, ARTS, SoS, MASS II) and four used drug-eluting stents (DES; FREEDOM, SYNTAX, VA CARDS, CARDia). At mean or median 5-year (or longest) follow-up, individuals with diabetes allocated to CABG had lower all-cause mortality than did those allocated to PCI (RR 0·67, 95% CI 0·52—0·86; p=0·002; I2=25%; 3131 patients, eight trials). Treatment effects in individuals without diabetes showed no mortality benefit (1·03, 0·77—1·37; p=0·78; I2=46%; 3790 patients, five trials; pinteraction=0.03). We identified no differences in outcome whether PCI was done with BMS or DES. When present, we identified no clear causes of heterogeneity.

Interpretation

In the modern era of stenting and optimum medical therapy, revascularisation of patients with diabetes and multivessel disease by CABG decreases long-term mortality by about a third compared with PCI using either BMS or DES. CABG should be strongly considered for these patients.

Transparent nanocrystalline yttria-stabilized-zirconia calvarium prosthesis- This may have implications in other areas also!

Abstract 

Laser-based diagnostics and therapeutics show promise for many neurological disorders. However, the poor transparency of cranial bone (calvaria) limits the spatial resolution and interaction depth that can be achieved, thus constraining opportunity in this regard. Herein, we report preliminary results from efforts seeking to address this limitation through use of novel transparent cranial implants made from nanocrystalline yttria-stabilized zirconia (nc-YSZ). Using optical coherence tomography (OCT) imaging of underlying brain in an acute murine model, we show that signal strength is improved when imaging through nc-YSZ implants relative to native cranium. As such, this provides initial evidence supporting the feasibility of nc-YSZ as a transparent cranial implant material. Furthermore, it represents a crucial first step towards realization of an innovative new concept we are developing, which seeks to eventually provide a clinically-viable means for optically accessing the brain, on-demand, over large areas, and on a chronically-recurring basis, without need for repeated craniectomies.

Transparent cranial implants could serve as a critical enabler for laser-based diagnosis and treatment of many neurological disorders. However, the intrinsic brittleness of transparent implants reported thus far predisposes them to catastrophic fracture-based failure, thus limiting opportunity for clinical translation. Novel nanocrystalline transparent implants are reported herein that seek to address this limitation through use of zirconia, a tough ceramic with well-proven biocompatibility in other chronic implantation applications.

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