In the recent past it was observed that aspirin would be beneficial in the prevention of recurrent DVT and cardiovascular events if given as a secondary thromboprophylactic agent after initial anticoagulation. It was opined that this benefit of aspirin in the long run is due to the protection from the actions of cytokines circulating in the blood which seem to be higher in the group of patients.
Can we consider that the statins such as Atorvastatin, Rosuvastatin are helpful in the acute DVT to protect the patients from effects of cytokines?
In a recent study it was observed that IL-6, IL-8, P selectin were reduced by the 3 day course of 40 mg of atorvastatin. Thromb Res. 2013 Jun 20. pii: S0049-3848(13)00183-7. doi: 10.1016/j.thromres.2013.04.026. [Epub ahead of print]
This point needs to be studied further to determine role of statins in the acute deep vein thrombosis patients. If it is proved that we may be adding the statin to the heparin in the management of venous thromboembolism.
Can we consider that the statins such as Atorvastatin, Rosuvastatin are helpful in the acute DVT to protect the patients from effects of cytokines?
In a recent study it was observed that IL-6, IL-8, P selectin were reduced by the 3 day course of 40 mg of atorvastatin. Thromb Res. 2013 Jun 20. pii: S0049-3848(13)00183-7. doi: 10.1016/j.thromres.2013.04.026. [Epub ahead of print]
This point needs to be studied further to determine role of statins in the acute deep vein thrombosis patients. If it is proved that we may be adding the statin to the heparin in the management of venous thromboembolism.
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